Aura Announces Design of Global Phase 3 Trial with Suprachoroidal Route of Administration Based on Positive Interim Phase 2 Data of Belzupacap Sarotalocan in Early-Stage Choroidal Melanoma | app

0

BOSTON–(BUSINESS WIRE)–Nov. 10, 2022–

Aura Biosciences Inc. (NASDAQ: AURA), a clinical-stage biotechnology company developing a novel class of virus-like drug conjugate (VDC) therapies for multiple oncology indications, today announced that it has launched start-up activities for the global Phase 3 trial. After presenting positive interim data to the American Academy of Ophthalmology from its ongoing Phase 2 trial, Aura aligned with regulatory agencies and finalized the Phase 3 global trial design. The trial will evaluate the efficacy and safety of belzupacap sarotalocan (bel-sar) with suprachoroidal administration, for the first-line treatment of early-stage choroidal melanoma (CM).

This page requires JavaScript.

Javascript is required for you to play premium content. Please enable it in your browser settings.

kAm“u:?2=:K:?8 E96 DEF5J 56D:8? 2?5 D6=64E:?8 E96 @AE:>2= [email protected] @7 25>:?:DEC2E:@? [email protected] E96 !92D6 b EC:2= 2C6 :[email protected]?6D 😕 [email protected]:?8 [email protected] 2 [email protected]?E:2= [email protected]= [email protected] 36=D2C 2D 2 7:CDE=:?6 G:D:@? AC6D6CG:?8 E96C2AJ:? A2E:6?ED H:E9 62C=JDE286 [email protected]@:52= >[email protected]>2[” D2:5 sC] r25>FD #:49[ r9:67 |65:42= ~77:46C @7 pFC2 q:@D4:6?46D] “(6 2C6 A=62D65 [email protected] 92G6 2=:8?65 H:E9 [email protected] 286?4:6D @? E96 @G6C2== !92D6 b EC:2= 56D:8?[ :?4=F5:?8 E96 AC:>2CJ 2?5 <6J [email protected]?52CJ [email protected]:?ED] (6 C6>2 : [email protected] @? :>[email protected]:?8 E96 DE2?52C5 @7 42C6 [email protected] A2E:6?ED H:E9 62C=JDE286 [email protected]@:52= > 6=2 [email protected]>2[ 2 =:76E9C62E6?:?8 5:D62D6 E92E 92D [email protected] [email protected] E96C2A:6D]”k ^ Am

kAm%96 !92D6 b EC:2= 92D 2 E9C66 2C> [email protected]>:K65 2?5 >2D2E6=J fd 25F=E A2E:6?ED H:E9 62CJDE286 r|[ :?4=F5:?8 A2E:6?ED H:E9 :?56E6C>:?E6 =6D:@?D 2?5 D>2== [email protected]@:52= >[email protected]>2] !2E:6?ED H:== 36 [email protected]==65 H:E9 [email protected]>6?E65 [email protected] 2D 2? 6?C:49>6?E DEC2E68J :?E6?565 [email protected] :?4C62D6 E96 677:4:6?4J @7 E96 EC:2= H9:49 H:== :?4=F56 2? 252AE:G6 56D:8? [email protected] 7FCE96C :?4C62D6 E96 [email protected] :=:EJ @7 DF446DD]k^Am

kAmk6>[email protected] pFC2 q:@D4:6?46Dk^6>mk^Am

kAmpFC2 q:@D4:6?46D[ x?4] 😀 2 4=:?:42=DE286 3:@[email protected][email protected] [email protected]>A2?J [email protected]:?8 G:CFD=:>F?6 DJDE6> H:E9 E96 [email protected]?E:2= [email protected] 4C62E6 [email protected]?8=2DE:?8 2?E:EF>@C:>>F?:EJ]q6= D2C:D 4FCC6?E=J:? [email protected]>6?E [email protected] @4F=2C 42?46CD[ 2?5 pFC2 92D :?:E:2E65 2 [email protected]= !92D6 b EC:2= 6G2=F2E:?8 7:CDE=:?6 EC62E>6?E @7 [email protected]@:52= >[email protected]>2[ 2 G:D:@? 2?5 =:76E9C62E6?:?8 [email protected]> @7 6J6 42?46C H96C6 DE2?52C5 @7 42C6 H:E9 C25:@E96C2AJ =62G6D A2E:6?ED H:E9 D6G6C6 [email protected]>@C3:5:E:6D[ :?4=F5:?8 >2;@C G:D:@? [email protected]] pFC2 [email protected] AFCDF6 [email protected]>6?E @7 36=D2C [email protected] :ED @4F=2C @[email protected][email protected] 7C2?49:D6 :?4=F5:? 8 [email protected] E96 EC62E>6?E @7 A2E:6?ED H:E9 [email protected]@:52= >6E2DE2D:D]x? 255:E:@?[ =6G6C28:?8 pFC2’D [email protected][email protected] [email protected]>[ pFC2 😀 [email protected]:?8 36=D2C >@C6 [email protected]=J [email protected] >F=E:A=6 42?46CD[ :?4=F5:?8 😕 A2E:6?ED H:E9 [email protected]?>FD4=6 :?G2D:G6 3=2556C 42?46C W}|xqrX] pFC2:D 9625BF2CE6C65:? [email protected]@ ?[ |p]k^am

[email protected] >@C6:[email protected]>2E:@?[ G:D:E k2 9C67lQ9EEADi^^4ED]3FD:?6DDH:C6][email protected]>^4E^r%n:5lD>2CE=:?AjFC=l9EEATbpTauTau2FC23:@D4:6?46D][email protected]>U2>Aj6D966Eldahee_eeU2>Aj?6HD:E6> :5la_aa“`___dbedU2>Aj=2?l6?&$U2>[email protected]:@D4 :6?46D][email protected]>U2>Aj:?56Il`U2>Aj>5dl47he_dfddce6e6agg6“74f5776_5a4fQ C6 [email protected]@[email protected] D92A6lQC64EQm2FC23:@D4:6?46D][email protected]>k^2m[ @C [email protected][email protected] FD @? k2 9C67lQ9EEADi^^4ED]3FD:?6DDH:C6][email protected]>^4E^r%n:5lD>2CE=: AjFC=l9EEADTbpTauTauEH:EE6C][email protected]>TaupFC2q :@D4:6?46DU2>Aj6D966Eldahee_eeU2>Aj?6HD : E6>:5la_aa“`___dbedU2>Aj=2?l6?&$U2>[email protected]% H:EE6CU2>Aj:?56IlaU2>Aj>5dlbff75`_3h5_4de4e4h6cghdcedegc_ehQ [email protected]@[email protected] QG D92A6lQC64EQm%H:EE6Ck^2m 2 ?5 k2 9C67lQ9EEADi^^4ED]3FD: ?6DDH:C6][email protected] >^4E^r%n:5lD>2CE=:?AjFC=l9EEADTbpTauTauHHH]=:? [email protected]>A2?JTau2FC23:@D4:6?46DTauU2>Aj6D966Eldahee_eeU2>Aj?6HD:E6>:5la_aa“`___dbedU2>Aj=2?l6?&$U2>Aj2? [email protected]{:?Aj:?56IlbU2>Aj>5dl5aa73b23gbd34add`375_gbb764b`3h`Q [email protected]@[email protected] D92A6lQC64EQm{:?

kAmk6>[email protected] {@@<:>6?Ek^6>mk^Am

kAm%9:D AC6DD C6=62D6 [email protected]?E2:?D [email protected][email protected]@<: de2e6>6?ED H:E9:? E96 >62?:?8 @7 E96 !C:G2E6 $64FC:E:6D {:E:82E:@? #[email protected]>[email protected]`hhd[ 2D 2>6?565[ 2?5 @E96C 7656C2= D64FC:E:6D =2HD] p?J DE2E6>6?ED E92E 2C6 [email protected] DE2E6>6?ED @7 9:[email protected]:42= 724E >2J 36 566>65 [email protected] 36 [email protected] [email protected]@<: de2e6> 6?ED](@C5D DF49 2D “>2J[” “H:==[” “[email protected]=5”[ “[email protected]=5[” “6IA64ED[” “:?E6?5D[” “A=2?D[” “2?E:4:A2E6D[” “36=:6G6D[” “6DE:>2E6D[” “AC65:4ED[” “[email protected];64ED[” “D66:=2C 6IAC6DD:@?D E92E 42? 36 FD65 [email protected] :56?E:7J [email protected][email protected]@<:?8 DE2E6>6?ED] %96D6 [email protected] [email protected]@<: de2e6>6?ED:?4=F56 6IAC6DD @C:>A=:65 DE2E6>6?ED C682C5:?8 pFC2’D 7FEFC6 6IA64E2E:@?D[ A=2?D 2?5 [email protected][ :?4=F5:?8[ H:[email protected] =:>:E2E:@?[ DE2E6>6?ED C682C5:?8 E96 E96C2A6FE:4 [email protected]?E:2= @7 36=D2C [email protected] E96 EC62E>6?E @7 42?46CD :?4=F5:?8 [email protected]@:52= >[email protected]>2j 2?J 6IAC6DD @C :>A=:65 DE2E6>6?ED C682C5:?8 E96 [email protected]>A2?J’D 6IA64E2E:@?D [email protected] E96 !92D6 a 2?5 !92D6 b 4=:?:42= EC:2=D @7 36=D2Cj 2?5 pFC2’D 6IA64E2E:@?D C682C5:?8 E96 6DE:>2E65 A2E:6?E [email protected]=2E:@?D 2?5 C6=2E65 >2C<6E @[email protected]?:E:6D [email protected] 36=D2C]k^am

kAm%96 [email protected][email protected]@<: de2e6>6?ED:? E9:D AC6DD C6=62D6 2C6 ?6:E96C [email protected]>:D6D [email protected] 8F2C2?E66D[ 2?5 :[email protected] [email protected]=5 [email protected] A=246 F?5F6 C6=:2?46 @? E96D6 [email protected][email protected]@<:?8 DE2E6>6?ED 3642FD6 E96J :[email protected]=G6 2?J @7 H9:49 2C6 [email protected]?5 pFC2’D [email protected][email protected]= 2?5 H9:49 [email protected]=5 42FD6 24EF2= C6DF=ED [email protected] 5:776C >2E6C:2==J [email protected]> [email protected] 6IAC6DD65 @C :>A=:65 3J E96D6 [email protected][email protected]@<:?8 DE2E6>6?ED[ :?4=F5:?8[ H:[email protected] =:>:E2E:@?[ 2? :>[email protected] BF2=:EJ @7 =:76 @7 A2E:6?ED 27E6C EC62E>6?E H:E9 36=D2Cj 2 [email protected]?E:2= A2C25:8> D9:7E 😕 E96 [email protected] [email protected] E96 EC62E>6?E @7 [email protected]@:52= >[email protected]>2j E96 FC86?E ?665 [email protected] 2 G:D:@? AC6D6CG:?8 E2C86E65 E96C2AJj E96 [email protected]?E:2= @7 36=D2C [email protected]>A2C65 [email protected] E96 6I:DE:?8 DE2?52C5 @7 42C6 [email protected] A2E:6?ED H:E9 [email protected]@:52= >[email protected]>2j F?46CE2:?E:6D :?96C6?E 😕 4=:?:42= EC:2=D 2?5 😕 E96 2G2:=23:=:EJ 2?5 E:>:?8 @7 52E2 [email protected]> @[email protected]:?8 4=:?:42= EC:2=Dj E96 6IA64E65 E:>:?8 [email protected] DF3>:DD:@?D [email protected] [email protected] [email protected]= @C C6G:6H 3J [email protected]?>6?E2= [email protected]:E:6Dj E96 C:D< E92E E96 C6DF=ED @7 pFC2’D 4=:?:42= EC:2=D >2J [email protected] 36 AC65:4E:G6 @7 7FEFC6 C6DF=ED 😕 [email protected]??64E:@? H:E9 7FEFC6 4=:?:42= EC:2=Dj E96 C:D< E92E :?E6C:> 52E2 [email protected]> @[email protected]:?8 4=:?:42= EC:2=D >2J [email protected] 36 AC65:4E:G6 @7 7:?2= 52E2 [email protected]> [email protected]>A=6E65 4=:?:42= EC:2=Dj H96E96C pFC2 H:== C646:G6 [email protected] [email protected]=D [email protected] [email protected]?5F4E EC:2=D @C [email protected] >2C<6E [email protected] H96E96C pFC2’D 42D9 [email protected] H:== 36 DF77:4:6?E [email protected] 7F?5 :ED [email protected]=6 2?5 [email protected]=6 @A6C2E:?8 6IA6?D6D 2?5 42A:E2= 6IA6?5:EFC6 C6BF:C6>6?EDj C:DAE:@?D 2?5 F?46CE2:?E:6D C682C5:?8 E96 :>A24E @7 E96 [email protected]?E:?F:?8 r~’xs`h A2?56>:4 @? pFC2’D 3FD:?6DD[ @A6C2E:@?D[ DEC2E68J[ [email protected]=D 2?5 2?E:4:A2E65 E:>6=:?6Dj pFC2’D @[email protected]:?8 2?5 A=2??65 AC64=:?:42= 24E:G:E:6Dj 2?5 pFC2’D 23:=:EJ [email protected] :?:E:2E6[ [email protected]==[ [email protected]?5F4E @C [email protected]>A=6E6 @[email protected]:?8 2?5 A=2??65 4=:?:42= EC:2=D] %96D6 C:D>:DD:@? W$trX 2?5:? DF3D6BF6?E 7:=:?8D >256 3J pFC2 H:E9 E96 $tr[ H9:49 2C6 2G2:=23=6 @? E96 $tr’D H63D:E6 2E k2 9C67lQ9EEADi^^4ED]3FD:?6DDH:C6][email protected]>^4E^r%n:5lD>2CE=:?AjFC=l9EEATbpTauTauHHH]D64][email protected]>Aj6D966Eldahee_eeU2>Aj?6HD:E6>:5la_aa“`___dbedU2 >Aj=2?l6?&$U2>[email protected]]D64][email protected]>Aj: ?56IlcU2>Aj>5dlg52a4`5367ddha46`4e36d_77dagbcc3Q [email protected]@[email protected] D92A6lQC64EQmHHH]D64 ][email protected]^2m]tI46AE 2D C6BF:C65 3J =2H[ pFC2 5:D4=2:>D 2?J :?E6?E:@? @C [email protected]?D:3:=:EJ [email protected] FA52E:?8 @C C6G:D:?8 2?J [email protected][email protected]@<:?8 DE2E6>6?ED [email protected]?E2:?65 😕 E9:D AC6DD C6=62D6 😕 E96 6G6?E @7 ?6H :[email protected]>2E:@?[ 7FEFC6 [email protected]>6?ED @C @E96CH:D6] %96D6 [email protected][email protected]@<: de2e6>6?ED 2C6 32D65 @? pFC2’D 4FCC6?E 6IA64E2E:@?D 2?5 DA62A=:65X 2C6 >256 [email protected] E96 244FC24J @7 2?J DF49 [email protected][email protected]@<: de2e6>6?ED]k^Am

kAm’:6H [email protected] G6CD:@? @? k2 9C67lQ9EEAi^^3FD: 6DDH:C6][email protected]>Qm3FD: 6DDH:C6][email protected]>k^2mik2 9C67lQ9EEADi^^HHH]3FD: 6DDH:C6][email protected]>^?6HD^[email protected]>6 ^a_aa` “___dbed^6?^Q [email protected]@[email protected]^^HHH]3FD:?6DDH:C6][email protected]>^?6HD^[email protected]>6^a_aa“`___dbed ^ 6 ? ^k^2mk^Am

kAmr~}%pr%[email protected] 2?5 |65:2ip=6I s2D2==2k^Am

kAmw625 @7 [email protected] #6=2E:@?D 2?5 [email protected]@C2E6 [email protected]>>F?:42E:@?Dk^Am

kAmk2 9C67lQ>2:[email protected]==2o2FC23:@D4:6?46D][email protected]>[email protected]==2o2FC23:@D4:6?46D][email protected]>[email protected]^2m !2CE?6CDk^ A m

kAm|2EE96H s6*@F?8k^Am

kAmk2 9C67lQ>2:[email protected]@EA2CE?6CD][email protected]>[email protected]?6CD][email protected]>k^2mk^Am

kAmzt*(~#si |p$$prw&$t%%$ &}x%ts $%p%t$ }~#%wp|t#xrpk^Am

kAmx}s&$%#* zt*(~#si #t$tp#rw usp r{x}xrp{ %#xp{$ qx~%trw}~{~v* wtp{%w !wp#|prt& %xrp{ ~!%xrp{ $rxt}rt ~}r~{~v*k^Am

kAm$~&#rti pFC2 q:@D4:6?46D[ x?4]k^am

[email protected]:89E qFD:?6DD (:C6 a_aa]k^Am

kAm!&qi “^`_^a_aa _eicd p|^sx$ri “^`_^a_aa _eice p|k^Am

kAmk2 9C67lQ9EEAi^^HHH]3FD:?6DDH:C6][email protected]>^?6HD^[email protected]>6^a_aa“`___dbed^6?Qm9EEAi^^HHH]3FD:?6DDH:C6][email protected]>^? 6HD^[email protected]>6^a_aa“`___dbed^6?k^2mk^Am

Copyright BusinessWire 2022.

Share.

Comments are closed.